Nitric oxide in the pathogenesis of vascular disease
نویسندگان
چکیده
منابع مشابه
Nitric oxide synthase: role in the genesis of vascular disease.
The product of nitric oxide (NO) synthase is the most potent endogenous vasodilator known. No not only is a potent vasodilator, it also inhibits platelet adherence and aggregation, reduces adherence of leukocytes to the endothelium, and suppresses proliferation of vascular smooth muscle cells. A number of disorders are associated with reduced synthesis and/or increased degradation of vascular N...
متن کاملNitric Oxide and Salmonella Pathogenesis
Nitric oxide (NO) and its congeners contribute to the innate immune response to Salmonella. This enteric pathogen is exposed to reactive nitrogen species (RNS) in the environment and at different anatomical locations during its infectious cycle in vertebrate hosts. Chemical generation of RNS enhances the gastric barrier to enteropathogenic bacteria, while products of the Salmonella pathogenicit...
متن کاملNitric oxide in vascular remodeling.
Vascular remodeling is a series of structural changes in blood vessels. Therefore, it may be conceivable that any humoral factors and physical forces acting on the vascular wall are involved in the remodeling processes. Cells in the vascular wall respond to the humoral and physical factors and may induce extracellular matrix, cell adhesion molecules and other humoral factors. They even grow so ...
متن کاملThe role of nitric oxide in the pathogenesis of Chagas disease.
In this chapter we summarize the protective and toxic effects of nitric oxide (NO) that are frequently seen in parallel during the infection with Trypanosoma cruzi. The killing of trypomastigotes is dependent on the production of NO which is catalyzed by the inducible NO synthase (iNOS). The cytokines IFN-gamma and TNF-alpha and several chemoatractants molecules, which act on G protein-coupled ...
متن کاملPathogenesis of Vascular Disease
Long study of human post-mortem material and of the arterial disease in rabbits that follows cholesterol feeding has not yet resulted in an understanding of the pathogenesis of arteriosclerosis. Although the focal distribution of the lesions in man and the partition of their contained lipids suggest interactions of local and hemic factors, it has proven difficult to determine either the nature ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Pathology
سال: 2000
ISSN: 0022-3417,1096-9896
DOI: 10.1002/(sici)1096-9896(200002)190:3<244::aid-path575>3.0.co;2-8